Gall Bladder

Gallbladder Cancer is a cancer that starts in the gallbladder. To understand this cancer, it helps to know about the gallbladder and what it does.The gallbladder is a small, pear-shaped organ under the liver. Both the liver and the gallbladder are behind the right lower ribs. In adults, the gallbladder is usually about 3 to 4 inches long and normally no wider than an inch.

The gallbladder is helpful, but you do not need it to live. Many people have their gallbladders removed and go on to live normal lives.

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What are the risk factors for Gallbladder Cancer?

A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed.
But having a risk factor, or even several risk factors, does not mean that a person will get the disease. And many people who get the disease may have few or no known risk factors. Many of causes of this cancer are related in some way to chronic inflammation (irritation and swelling) in the gallbladder.

Gallstones

Gallstones are the most common risk factor for gallbladder cancer. Gallstones are pebble-like collections of cholesterol and other substances that form in the gallbladder and can cause chronic inflammation. At least 3 out of 4 people with gallbladder cancer have gallstones when they are diagnosed. But gallstones are very common, and gallbladder cancer is quite rare, especially in the United States. Most people with gallstones never develop gallbladder cancer.

Porcelain Gallbladder

Porcelain gallbladder is a condition in which the wall of the gallbladder becomes covered with calcium deposits. It sometimes occurs after long-term inflammation of the gallbladder (cholecystitis), which can be caused by gallstones. People with this condition have a higher risk of developing gallbladder cancer (possibly because both conditions can be related to inflammation).

Female Gender

In western countries, Gallbladder cancer occurs more often in women. Gallstones and gallbladder inflammation are important risk factors for gallbladder cancer and are also much more common in women than men.

Obesity

Patients with gallbladder cancer are more often overweight or obese than people without this disease. Obesity is also a risk factor for gallstones.

Other Symptoms

Less common symptoms of gallbladder cancer include:

Loss of appetite

Weight loss

Swelling in the abdomen (belly)

Fever

Itchy skin

Dark urine

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